Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.
Auteurs : Rosana Crespo [Argentine] ; Boris E. Rodenak-Kladniew [Argentine] ; María A. Castro [Argentine] ; María V. Sober N [Argentine] ; Sabrina M L. Lavarías [Argentine]Source :
- Chemico-biological interactions [ 1872-7786 ] ; 2020.
Descripteurs français
- KwdFr :
- Cellules A549 (MeSH), Cellules HepG2 (MeSH), Humains (MeSH), Prolifération cellulaire (MeSH), Relation dose-effet des médicaments (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Structure moléculaire (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques).
- MESH :
- effets des médicaments et des substances chimiques : Stress oxydatif, Survie cellulaire.
- Cellules A549, Cellules HepG2, Humains, Prolifération cellulaire, Relation dose-effet des médicaments, Structure moléculaire.
English descriptors
- KwdEn :
- A549 Cells (MeSH), Acyclic Monoterpenes (administration & dosage), Acyclic Monoterpenes (chemistry), Acyclic Monoterpenes (pharmacology), Cell Proliferation (MeSH), Cell Survival (drug effects), Dose-Response Relationship, Drug (MeSH), Hep G2 Cells (MeSH), Humans (MeSH), Molecular Structure (MeSH), Oxidative Stress (drug effects).
- MESH :
- chemical , administration & dosage : Acyclic Monoterpenes.
- chemical , chemistry : Acyclic Monoterpenes.
- chemical , pharmacology : Acyclic Monoterpenes.
- drug effects : Cell Survival, Oxidative Stress.
- A549 Cells, Cell Proliferation, Dose-Response Relationship, Drug, Hep G2 Cells, Humans, Molecular Structure.
Abstract
Geraniol (GOH), like other plant-derived natural bioactive compounds, has been found to possess antiproliferative properties that are essential to cope with malignant tumors. However, the mechanisms of molecular action of GOH are not fully elucidated. The aim of this study was to evaluate the effect of GOH on some oxidative parameters in human tumor cell lines (HepG2 and A549). Cytotoxicity evaluated in cell lines by the MTT assay, genotoxicity by the comet assay, and lipid peroxidation by the TBARS. The activities of antioxidant the enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), were also analyzed. Additionally, intracellular reactive oxygen species (ROS), nitric oxide, and lactate production were determined in HepG2 cells. Both tumor cell lines showed a clear concentration-dependent response to GOH in several of the parameters evaluated. Lipids turned out to be more sensitive than DNA to oxidative damage induced by GOH. TBARS levels increased with respect to control (p < 0.05) by 33% and 122% in HepG2 and A549 cells, respectively treated with 200 μM GOH. However, GOH caused a statistically significant decrease in SOD and CAT activities in HepG2 cells only. GST was not affected in any cell lines. GOH induced the production of ROS but not nitric oxide in HepG2, which shows that ROS were mainly responsible for oxidative damage. Lactate release increased statistically significantly compared to control (p < 0.001), by 41% and 86% at 200 and 800 μM GOH respectively, showing that this monoterpene also affected the glycolytic pathway in HepG2 cells. These results suggest that oxidative stress could mediate the anti-proliferative effects of GOH in HepG2 and A549 cells.
DOI: 10.1016/j.cbi.2020.109029
PubMed: 32119866
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.</title><author><name sortKey="Crespo, Rosana" sort="Crespo, Rosana" uniqKey="Crespo R" first="Rosana" last="Crespo">Rosana Crespo</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Rodenak Kladniew, Boris E" sort="Rodenak Kladniew, Boris E" uniqKey="Rodenak Kladniew B" first="Boris E" last="Rodenak-Kladniew">Boris E. Rodenak-Kladniew</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Castro, Maria A" sort="Castro, Maria A" uniqKey="Castro M" first="María A" last="Castro">María A. Castro</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Sober N, Maria V" sort="Sober N, Maria V" uniqKey="Sober N M" first="María V" last="Sober N">María V. Sober N</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Lavarias, Sabrina M L" sort="Lavarias, Sabrina M L" uniqKey="Lavarias S" first="Sabrina M L" last="Lavarías">Sabrina M L. Lavarías</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Limnología de La Plata"Dr. Raúl A. Ringuelet" (ILPLA) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina. Electronic address: sabrinalavarias@ilpla.edu.ar.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Limnología de La Plata"Dr. Raúl A. Ringuelet" (ILPLA) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32119866</idno><idno type="pmid">32119866</idno><idno type="doi">10.1016/j.cbi.2020.109029</idno><idno type="wicri:Area/Main/Corpus">000199</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000199</idno><idno type="wicri:Area/Main/Curation">000199</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000199</idno><idno type="wicri:Area/Main/Exploration">000199</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.</title><author><name sortKey="Crespo, Rosana" sort="Crespo, Rosana" uniqKey="Crespo R" first="Rosana" last="Crespo">Rosana Crespo</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Rodenak Kladniew, Boris E" sort="Rodenak Kladniew, Boris E" uniqKey="Rodenak Kladniew B" first="Boris E" last="Rodenak-Kladniew">Boris E. Rodenak-Kladniew</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Castro, Maria A" sort="Castro, Maria A" uniqKey="Castro M" first="María A" last="Castro">María A. Castro</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Sober N, Maria V" sort="Sober N, Maria V" uniqKey="Sober N M" first="María V" last="Sober N">María V. Sober N</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author><author><name sortKey="Lavarias, Sabrina M L" sort="Lavarias, Sabrina M L" uniqKey="Lavarias S" first="Sabrina M L" last="Lavarías">Sabrina M L. Lavarías</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Limnología de La Plata"Dr. Raúl A. Ringuelet" (ILPLA) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina. Electronic address: sabrinalavarias@ilpla.edu.ar.</nlm:affiliation><country xml:lang="fr">Argentine</country><wicri:regionArea>Instituto de Limnología de La Plata"Dr. Raúl A. Ringuelet" (ILPLA) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata</wicri:regionArea><wicri:noRegion>La Plata</wicri:noRegion></affiliation></author></analytic><series><title level="j">Chemico-biological interactions</title><idno type="eISSN">1872-7786</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells (MeSH)</term><term>Acyclic Monoterpenes (administration & dosage)</term><term>Acyclic Monoterpenes (chemistry)</term><term>Acyclic Monoterpenes (pharmacology)</term><term>Cell Proliferation (MeSH)</term><term>Cell Survival (drug effects)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Hep G2 Cells (MeSH)</term><term>Humans (MeSH)</term><term>Molecular Structure (MeSH)</term><term>Oxidative Stress (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules A549 (MeSH)</term><term>Cellules HepG2 (MeSH)</term><term>Humains (MeSH)</term><term>Prolifération cellulaire (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Stress oxydatif (effets des médicaments et des substances chimiques)</term><term>Structure moléculaire (MeSH)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Acyclic Monoterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Acyclic Monoterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Acyclic Monoterpenes</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Stress oxydatif</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Cell Proliferation</term><term>Dose-Response Relationship, Drug</term><term>Hep G2 Cells</term><term>Humans</term><term>Molecular Structure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules A549</term><term>Cellules HepG2</term><term>Humains</term><term>Prolifération cellulaire</term><term>Relation dose-effet des médicaments</term><term>Structure moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Geraniol (GOH), like other plant-derived natural bioactive compounds, has been found to possess antiproliferative properties that are essential to cope with malignant tumors. However, the mechanisms of molecular action of GOH are not fully elucidated. The aim of this study was to evaluate the effect of GOH on some oxidative parameters in human tumor cell lines (HepG2 and A549). Cytotoxicity evaluated in cell lines by the MTT assay, genotoxicity by the comet assay, and lipid peroxidation by the TBARS. The activities of antioxidant the enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), were also analyzed. Additionally, intracellular reactive oxygen species (ROS), nitric oxide, and lactate production were determined in HepG2 cells. Both tumor cell lines showed a clear concentration-dependent response to GOH in several of the parameters evaluated. Lipids turned out to be more sensitive than DNA to oxidative damage induced by GOH. TBARS levels increased with respect to control (p < 0.05) by 33% and 122% in HepG2 and A549 cells, respectively treated with 200 μM GOH. However, GOH caused a statistically significant decrease in SOD and CAT activities in HepG2 cells only. GST was not affected in any cell lines. GOH induced the production of ROS but not nitric oxide in HepG2, which shows that ROS were mainly responsible for oxidative damage. Lactate release increased statistically significantly compared to control (p < 0.001), by 41% and 86% at 200 and 800 μM GOH respectively, showing that this monoterpene also affected the glycolytic pathway in HepG2 cells. These results suggest that oxidative stress could mediate the anti-proliferative effects of GOH in HepG2 and A549 cells.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32119866</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7786</ISSN><JournalIssue CitedMedium="Internet"><Volume>320</Volume><PubDate><Year>2020</Year><Month>Apr</Month><Day>01</Day></PubDate></JournalIssue><Title>Chemico-biological interactions</Title><ISOAbbreviation>Chem Biol Interact</ISOAbbreviation></Journal><ArticleTitle>Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.</ArticleTitle><Pagination><MedlinePgn>109029</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0009-2797(19)32010-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cbi.2020.109029</ELocationID><Abstract><AbstractText>Geraniol (GOH), like other plant-derived natural bioactive compounds, has been found to possess antiproliferative properties that are essential to cope with malignant tumors. However, the mechanisms of molecular action of GOH are not fully elucidated. The aim of this study was to evaluate the effect of GOH on some oxidative parameters in human tumor cell lines (HepG2 and A549). Cytotoxicity evaluated in cell lines by the MTT assay, genotoxicity by the comet assay, and lipid peroxidation by the TBARS. The activities of antioxidant the enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST), were also analyzed. Additionally, intracellular reactive oxygen species (ROS), nitric oxide, and lactate production were determined in HepG2 cells. Both tumor cell lines showed a clear concentration-dependent response to GOH in several of the parameters evaluated. Lipids turned out to be more sensitive than DNA to oxidative damage induced by GOH. TBARS levels increased with respect to control (p < 0.05) by 33% and 122% in HepG2 and A549 cells, respectively treated with 200 μM GOH. However, GOH caused a statistically significant decrease in SOD and CAT activities in HepG2 cells only. GST was not affected in any cell lines. GOH induced the production of ROS but not nitric oxide in HepG2, which shows that ROS were mainly responsible for oxidative damage. Lactate release increased statistically significantly compared to control (p < 0.001), by 41% and 86% at 200 and 800 μM GOH respectively, showing that this monoterpene also affected the glycolytic pathway in HepG2 cells. These results suggest that oxidative stress could mediate the anti-proliferative effects of GOH in HepG2 and A549 cells.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Crespo</LastName><ForeName>Rosana</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodenak-Kladniew</LastName><ForeName>Boris E</ForeName><Initials>BE</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro</LastName><ForeName>María A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soberón</LastName><ForeName>María V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavarías</LastName><ForeName>Sabrina M L</ForeName><Initials>SML</Initials><AffiliationInfo><Affiliation>Instituto de Limnología de La Plata"Dr. Raúl A. Ringuelet" (ILPLA) CCT CONICET La Plata-Universidad Nacional de La Plata (UNLP), La Plata, Argentina. Electronic address: sabrinalavarias@ilpla.edu.ar.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Chem Biol Interact</MedlineTA><NlmUniqueID>0227276</NlmUniqueID><ISSNLinking>0009-2797</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000080462">Acyclic Monoterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>L837108USY</RegistryNumber><NameOfSubstance UI="C007836">geraniol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000072283" MajorTopicYN="N">A549 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000080462" MajorTopicYN="N">Acyclic Monoterpenes</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049109" MajorTopicYN="Y">Cell Proliferation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D056945" MajorTopicYN="N">Hep G2 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Essential oils</Keyword><Keyword MajorTopicYN="N">Geraniol</Keyword><Keyword MajorTopicYN="N">Glycolytic pathway</Keyword><Keyword MajorTopicYN="N">Human tumor cell lines</Keyword><Keyword MajorTopicYN="N">Oxidative stress</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32119866</ArticleId><ArticleId IdType="pii">S0009-2797(19)32010-1</ArticleId><ArticleId IdType="doi">10.1016/j.cbi.2020.109029</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Argentine</li></country></list><tree><country name="Argentine"><noRegion><name sortKey="Crespo, Rosana" sort="Crespo, Rosana" uniqKey="Crespo R" first="Rosana" last="Crespo">Rosana Crespo</name></noRegion><name sortKey="Castro, Maria A" sort="Castro, Maria A" uniqKey="Castro M" first="María A" last="Castro">María A. Castro</name><name sortKey="Lavarias, Sabrina M L" sort="Lavarias, Sabrina M L" uniqKey="Lavarias S" first="Sabrina M L" last="Lavarías">Sabrina M L. Lavarías</name><name sortKey="Rodenak Kladniew, Boris E" sort="Rodenak Kladniew, Boris E" uniqKey="Rodenak Kladniew B" first="Boris E" last="Rodenak-Kladniew">Boris E. Rodenak-Kladniew</name><name sortKey="Sober N, Maria V" sort="Sober N, Maria V" uniqKey="Sober N M" first="María V" last="Sober N">María V. Sober N</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PlantGlutaTransV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000121 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000121 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PlantGlutaTransV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32119866
|texte= Induction of oxidative stress as a possible mechanism by which geraniol affects the proliferation of human A549 and HepG2 tumor cells.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32119866" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PlantGlutaTransV1
| This area was generated with Dilib version V0.6.38. |  |